Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways.

@article{Wanninger2009AdiponectinstimulatedCR,
  title={Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways.},
  author={Josef Wanninger and Manfred Neumeier and Johanna Weigert and Sabrina Bauer and Thomas S. Weiss and Andreas Schaeffler and Corinna Krempl and Cornelia Bleyl and Charalampos Aslanidis and Juergen Schoelmerich and Christa Buechler},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2009},
  volume={297 3},
  pages={
          G611-8
        }
}
Adiponectin is believed to exert hepatoprotective effects and induces CXCL8, a chemokine that functions as a survival factor, in vascular cells. In the current study, it is demonstrated that adiponectin also induces CXCL8 expression in primary human hepatocytes but not in hepatocellular carcinoma cell lines. Knock down of the adiponectin receptor (AdipoR) 1 or AdipoR2 by small-interfering RNA indicates that AdipoR1 is involved in adiponectin-stimulated CXCL8 release. Adiponectin activates… CONTINUE READING

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