Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1.

  title={Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1.},
  author={Daisuke Kajimura and Ha Won Lee and Kyle J. Riley and Emilio Arteaga-Solis and M. A. Vilches Ferr{\'o}n and Bin Zhou and Christopher J. Clarke and Yusuf A. Hannun and Ronald A. Depinho and Xiangdong Edward Guo and J. John Mann and Gerard Karsenty},
  journal={Cell metabolism},
  volume={17 6},
The synthesis of adiponectin, an adipokine with ill-defined functions in animals fed a normal diet, is enhanced by the osteoblast-derived hormone osteocalcin. Here we show that adiponectin signals back in osteoblasts to hamper their proliferation and favor their apoptosis, altogether decreasing bone mass and circulating osteocalcin levels. Adiponectin fulfills these functions, independently of its known receptors and signaling pathways, by decreasing FoxO1 activity in a PI3-kinase-dependent… CONTINUE READING
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Receptor - mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

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