Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice.

  title={Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice.},
  author={Yoshihisa Okamoto and Shinji Kihara and Noriyuki Ouchi and Makoto Nishida and Yukio Arita and Masahiro Kumada and Koji Ohashi and Naohiko Sakai and Iichiro Shimomura and Hideki Kobayashi and Naoki Terasaka and Toshimori Inaba and Tohru Funahashi and Yuji Matsuzawa},
  volume={106 22},
BACKGROUND Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the injured artery from the plasma and suppressed endothelial inflammatory response and vascular smooth muscle cell proliferation, as well as macrophage-to-foam cell transformation in vitro. The current study investigated whether the increased plasma adiponectin could… CONTINUE READING
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