Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling.

@article{Xu2008AdiponectinPA,
  title={Adiponectin protects against angiotensin II or tumor necrosis factor alpha-induced endothelial cell monolayer hyperpermeability: role of cAMP/PKA signaling.},
  author={Shi-qiong Xu and Kalyankar Mahadev and Xiangdong Wu and Lauren Fuchsel and Sylvia Donnelly and Rosario G Scalia and Barry J. Goldstein},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 5},
  pages={899-905}
}
OBJECTIVE Angiotensin II (Ang II) and tumor necrosis factor (TNF)-alpha levels increase endothelial permeability, and we hypothesized that adiponectin suppressed these responses in a cAMP-dependent manner. METHODS AND RESULTS The effect of adiponectin on transendothelial electric resistance (TEER) and diffusion of albumin through human umbilical vein and bovine aortic endothelial cell monolayers induced by Ang II (100 nmol/L) or TNF-alpha (5 ng/mL) was measured. Treatment with the globular… CONTINUE READING
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