Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha.

@article{Fujita2008AdiponectinPA,
  title={Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha.},
  author={Koichi Fujita and Norikazu Maeda and Mina Sonoda and Koji Ohashi and Toshiyuki Hibuse and Hitoshi Nishizawa and M. Nishida and Aki Hiuge and Akifumi Kurata and Shinji Kihara and Iichiro Shimomura and Tohru Funahashi},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 5},
  pages={863-70}
}
OBJECTIVE Adiponectin is recognized as an antidiabetic, antiatherosclerotic, and anti-inflammatory protein derived from adipocytes. However, the role of adiponectin in cardiac fibrosis remains uncertain. We herein explore the effects of adiponectin on cardiac fibrosis induced by angiotensin II (Ang II). METHODS AND RESULTS Wild-type (WT), adiponectin knockout (Adipo-KO), and PPAR-alpha knockout (PPAR-alpha-KO) mice were infused with Ang II at 1.2 mg/kg/d. Severe cardiac fibrosis and left… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
79 Citations
32 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Similar Papers

Loading similar papers…