Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.

  title={Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype.},
  author={Koji Ohashi and Jennifer L. Parker and Noriyuki Ouchi and Akiko Higuchi and Joseph A. Vita and Noyan Gokce and Anette Amstrup Pedersen and Christoph Kalthoff and S\oren Tullin and Anette Graven Sams and Ross S. Summer and Kenneth Walsh},
  journal={The Journal of biological chemistry},
  volume={285 9},
It is established that the adipocyte-derived cytokine adiponectin protects against cardiovascular and metabolic diseases, but the effect of this adipokine on macrophage polarization, an important mediator of disease progression, has never been assessed. We hypothesized that adiponectin modulates macrophage polarization from that resembling a classically activated M1 phenotype to that resembling alternatively-activated M2 cells. Peritoneal macrophages and the stromal vascular fraction (SVF… CONTINUE READING
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