Adiponectin promotes functional recovery after podocyte ablation.

  title={Adiponectin promotes functional recovery after podocyte ablation.},
  author={Joseph M Rutkowski and Zhao V Wang and Ae Seo Deok Park and Jianning Zhang and Dihua Zhang and Ming Chang Hu and Orson W Moe and Katalin Suszt{\'a}k and Phillip E Scherer},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={24 2},
Low levels of the adipocyte-secreted protein adiponectin correlate with albuminuria in both mice and humans, but whether adiponectin has a causative role in modulating renal disease is unknown. Here, we first generated a mouse model that allows induction of caspase-8-mediated apoptosis specifically in podocytes upon injection of a construct-specific agent. These POD-ATTAC mice exhibited significant kidney damage, mimicking aspects of human renal disease, such as foot process effacement… CONTINUE READING

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