Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα dependent mechanism.

@article{Lin2010AdiponectinmediatedHO,
  title={Adiponectin-mediated heme oxygenase-1 induction protects against iron-induced liver injury via a PPARα dependent mechanism.},
  author={Heng Lin and Chun-Hsien Yu and Chih-Yu Jen and C. Cheng and Ying Hao Chou and Chih-Cheng Chang and S C Juan},
  journal={The American journal of pathology},
  year={2010},
  volume={177 4},
  pages={1697-709}
}
Protective effects of adiponectin (APN; an adipocytokine) were shown against various oxidative challenges; however, its therapeutic implications and the mechanisms underlying hepatic iron overload remain unclear. Herein, we show that the deleterious effects of iron dextran on liver function and iron deposition were significantly reversed by adiponectin gene therapy, which was accompanied by AMP-activated protein kinase (AMPK) phosphorylation and heme oxygenase (HO)-1 induction. Furthermore… CONTINUE READING
23 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…