Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators

@inproceedings{Choi2009AdiponectinMC,
  title={Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators},
  author={Hyun Mi Choi and Yeon-Ah Lee and Sang-Hoon Lee and Seung-Jae Hong and Dae-hyun Hahm and S Choi and Hyung In Yang and Myung-chul Yoo and Kyoung Soo Kim},
  booktitle={Arthritis research & therapy},
  year={2009}
}
INTRODUCTION The role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthritis (RA) in relation to the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). METHODS Synovial cells from RA patients were treated with adiponectin or interleukin (IL)-1beta for 24 hours. The culture supernatant was collected and… CONTINUE READING

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A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and Page 9 of 10 (page number not for citation purposes) Arthritis Research & Therapy

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