Adiponectin lowers glucose production by increasing SOGA.

  title={Adiponectin lowers glucose production by increasing SOGA.},
  author={Rachael B Cowherd and Melissa M Asmar and Jason M. Alderman and Elizabeth A Alderman and Alaina L. Garland and Walker H. Busby and Wanda Bodnar and Ivan Rusyn and Benjamin D. Medoff and Roland M. Tisch and Elizabeth Mayer-Davis and James A. Swenberg and Steven H Zeisel and Terry P. Combs},
  journal={The American journal of pathology},
  volume={177 4},
Adiponectin is a hormone that lowers glucose production by increasing liver insulin sensitivity. Insulin blocks the generation of biochemical intermediates for glucose production by inhibiting autophagy. However, autophagy is stimulated by an essential mediator of adiponectin action, AMPK. This deadlock led to our hypothesis that adiponectin inhibits autophagy through a novel mediator. Mass spectrometry revealed a novel protein that we call suppressor of glucose by autophagy (SOGA) in… CONTINUE READING
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