Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis.

@article{Staiger2005AdiponectinIF,
  title={Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis.},
  author={Katrin Staiger and Norbert Stefan and Harald Staiger and Mathias D. Brendel and Daniel Brandhorst and Reinhard Georg Bretzel and Fausto Machicao and Monika Kellerer and Michael Stumvoll and Andreas Fritsche and H G H{\"a}ring},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 12},
  pages={6707-13}
}
CONTEXT The adipokine adiponectin has insulin-sensitizing, antiatherogenic, and antiinflammatory properties. Mouse and human adiponectin receptor-1 and -2 have been cloned, both of which are expressed in various tissues and mediate effects of globular and full-length adiponectin. Whether adiponectin affects insulin secretion and beta-cell apoptosis and whether plasma adiponectin is associated with beta-cell function in humans is under investigation. DESIGN AND METHODS In human islets from… CONTINUE READING

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