Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity

@inproceedings{Chan2012AdiponectinIP,
  title={Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity in Amyloid-Beta Neurotoxicity},
  author={Koon Ho Chan and Karen Siu-Ling. Lam and On-Yin Cheng and Jason Kwan and Philip Ho and Kenneth King-yip Cheng and Sookja Kim Chung and Jessica Wing-Man Ho and Vivian Yawei Guo and Almin Xu},
  booktitle={PloS one},
  year={2012}
}
Beta-amyloid (Aβ ) neurotoxicity is important in Alzheimer's disease (AD) pathogenesis. Aβ neurotoxicity causes oxidative stress, inflammation and mitochondrial damage resulting in neuronal degeneration and death. Oxidative stress, inflammation and mitochondrial failure are also pathophysiological mechanisms of type 2 diabetes (T(2)DM) which is characterized by insulin resistance. Interestingly, T(2)DM increases risk to develop AD which is associated with reduced neuronal insulin sensitivity… CONTINUE READING
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