Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli.

@article{Tsatsanis2005AdiponectinIT,
  title={Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli.},
  author={Christos Tsatsanis and Vassiliki Zacharioudaki and Ariadne Androulidaki and Erini Dermitzaki and Ioannis Charalampopoulos and Vassilis Minas and Achilleas Gravanis and Andrew N. Margioris},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={335 4},
  pages={1254-63}
}
Adiponectin exerts anti-inflammatory effects via macrophages, suppressing the production of pro-inflammatory cytokines in response to bacterial lipopolysaccharide (LPS). Here, we provide experimental evidence that the "anti-inflammatory" effect of adiponectin may be due to an induction of macrophage tolerance: globular adiponectin (gAd) is a powerful… CONTINUE READING