Adiponectin induces CCL20 expression synergistically with IL-6 and TNF-α in THP-1 macrophages.

  title={Adiponectin induces CCL20 expression synergistically with IL-6 and TNF-α in THP-1 macrophages.},
  author={M. Suzuki and M. Mihara},
  volume={58 3},
  • M. Suzuki, M. Mihara
  • Published 2012
  • Chemistry, Medicine
  • Cytokine
  • Adiponectin (Ad) is an adipokine secreted from adipocytes. It is reported that Ad has many biological activities. However, its influence on inflammation is controversial. In the present study, we examined the influence of Ad on production of CCL20 from THP-1 macrophages. THP-1 macrophages were prepared from THP-1 monocytes by PMA treatment. THP-1 macrophages were cultured for 24h with Ad, IL-6, or TNF-α alone or with combinations of Ad and cytokines. CCL20 mRNA expression was then determined by… CONTINUE READING
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