Adiponectin in health and disease

@article{Oh2007AdiponectinIH,
  title={Adiponectin in health and disease},
  author={Deborah K. Oh and Theodore P. Ciaraldi and Robert R. Henry},
  journal={Diabetes},
  year={2007},
  volume={9}
}
Adipose tissue is an active metabolic tissue that secretes multiple metabolically important proteins, known as adipokines. Adiponectin is an important adipokine because of its beneficial effects on glucose and lipid metabolism. Low levels of adiponectin are associated with disease states such as diabetes and cardiovascular disease. Direct administration of adiponectin has been shown to be beneficial in animal models of diabetes, obesity and atherosclerosis. Adiponectin levels in humans can be… 
Adipokines and Inflammation: Focus on Cardiovascular Diseases
TLDR
The role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases are summarized.
Adiponectin and Type 1 Diabetes Mellitus in Children PSN
TLDR
Levels of the hormone are inversely correlated with BMI and body fat percentage in adults, and the association in infants and young children is less clear.
Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.
TLDR
This review aims to summarize recent advances on delineation of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin.
Relationship between adiponectin, obesity and insulin resistance.
TLDR
It is not clear whether adiponectin levels have any clinical significance for risk stratification in cardiovascular disease or if they simply reflect the activation of complex underlying mechanisms.
Basic Aspects of Adipokines in Bone Metabolism
TLDR
A review of the recent findings in basic research about the involvement of several adipokines in bone metabolism concludes that white adipose tissue is an endocrine organ able to secrete a wide variety of factors called adipokine.
Adipokines as emerging mediators of immune response and inflammation
TLDR
Progress in adipokine research is discussed, focusing particular attention to the roles of leptin, adiponectin, resistin, visfatin, and other recently identified adipokines in inflammatory, autoimmune and rheumatic diseases.
The complex role of adiponectin in chronic kidney disease.
Adipokines, systemic inflammation and exercise Adipokinele, inflamația sistemică și exercițiul fizic
TLDR
A short review of the literature underlining the roles of adipokines in inflammation and insulin resistance and the favorable effect of exercise that may reduce inflammation and ameliorate insulin resistance by inducing a favorable antiinflammatory adipokine profile is presented.
...
...

References

SHOWING 1-10 OF 86 REFERENCES
Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin.
TLDR
Body weight reduction increased the plasma levels of a protective adipocytokine, adiponectin, despite the reduction of the only tissue of its own synthesis, suggesting that the expression of adip onectin is under feedback inhibition in obesity.
Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women
TLDR
Levels of adiponectin, which are associated with markers of chronic subclinical inflammation, could be significantly increased after weight loss in morbidly obese patients, and was more pronounced in patients with NGT compared to those with T2D and IGT.
Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes.
TLDR
The hypothesis that increased adiponectin levels might be associated with better glycemic control, better lipid profile, and reduced inflammation in diabetic subjects is supported.
Adiponectin and adiponectin receptors.
TLDR
It is shown that AdipoR1 and AdIPoR2 serve as receptors for globular and full-length adiponectin and mediate increased AMP-activated protein kinase, peroxisome proliferator-activated receptor-alpha ligand activities, and glucose uptake and fatty-acid oxidation by adiponECTin.
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
TLDR
Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter.
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
TLDR
It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes.
TLDR
The relationship between adiponectin and glucose tolerance in pregnancy is investigated to suggest that hypoadiponectinemia may be an important factor in the development of insulin resistance and the pathophysiology of type 2 diabetes.
Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes.
TLDR
Higher adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in diabetic women, and all other associations observed herein were consistent among obese and nonobese diabetic women.
Adiponectin: more than just another fat cell hormone?
TLDR
Adiponectin has been postulated to play an important role in the modulation of glucose and lipid metabolism in insulin-sensitive tissues in both humans and animals.
...
...