Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity.

@article{Li2007AdiponectinIE,
  title={Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity.},
  author={Rong Li and Wen-qing Wang and Haifeng Zhang and Xinchung Yang and Qian Fan and Theodore A. Christopher and Bernard L. Lopez and Ling Jie Tao and Barry J. Goldstein and Feng Gao and Xin L. Ma},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 6},
  pages={E1703-8}
}
Plasma adiponectin level is significantly reduced in patients with metabolic syndrome, and vascular dysfunction is an important pathological event in these patients. However, whether adiponectin may protect endothelial cells and attenuate endothelial dysfunction caused by metabolic disorders remains largely unknown. Adult rats were fed with a regular or a high-fat diet for 14 wk. The aorta was isolated, and vascular segments were incubated with vehicle or the globular domain of adiponectin (gAd… CONTINUE READING