Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.

@article{Awazawa2009AdiponectinEI,
  title={Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway.},
  author={Motoharu Awazawa and Kohjiro Ueki and Kazunori Inabe and Toshimasa Yamauchi and Naoto Kubota and Kazuma Kaneko and Masatoshi Kobayashi and Aya Iwane and Takayoshi Sasako and Yukiko Okazaki and Mitsuru Ohsugi and Iseki Takamoto and Satoshi Yamashita and Hiroshi Asahara and S Yukimatu Akira and Masato Kasuga and Takashi Kadowaki},
  journal={Cell metabolism},
  year={2009},
  volume={13 4},
  pages={
          401-412
        }
}
Insulin resistance is often associated with impeded insulin signaling due either to decreased concentrations or functional modifications of crucial signaling molecules including insulin receptor substrates (IRS) in the liver. Many actions of adiponectin, a well-recognized antidiabetic adipokine, are currently attributed to the activation of two critical molecules downstream of AdipoR1 and R2: AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor α (PPARα). However, the… CONTINUE READING
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