Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema.

@article{Miller2010AdiponectindeficientMA,
  title={Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema.},
  author={Marina Miller and Alexa K Pham and Jae Youn Cho and Peter Rosenthal and David H. Broide},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2010},
  volume={299 6},
  pages={L834-42}
}
Adiponectin is a cytokine with both proinflammatory and anti-inflammatory properties that is expressed in epithelial cells in the airway in chronic obstructive pulmonary disease-emphysema (COPD-E). To determine whether adiponectin modulates levels of lung inflammation in tobacco smoke-induced COPD-E, we used a mouse model of COPD-E in which either adiponectin-deficient or wild-type (WT) mice were exposed to tobacco smoke for 6 mo. Outcomes associated with tobacco smoke-induced COPD-E were… CONTINUE READING

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