Adiponectin concentrations: a genome-wide association study.


Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10(-15) in the initial sample, p = 6.58 × 10(-39) in the second genome-wide sample, and p = 2.12 × 10(-32) in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10(-83). The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10(-58)) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.

DOI: 10.1016/j.ajhg.2010.09.004
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@article{Jee2010AdiponectinCA, title={Adiponectin concentrations: a genome-wide association study.}, author={Sun Ha Jee and Jae Woong Sull and Jong-Eun Lee and Chol Shin and Jongkeun Park and Heejin Kimm and Eun-Young Cho and E Kyung Shin and Ji Eun Yun and Ji Wan Park and Sang Yeun Kim and Sun Ju Lee and Eun Jung Jee and Inkyung Baik and Linda Kao and Sungjoo Kim Yoon and Yangsoo Jang and Terri H. Beaty}, journal={American journal of human genetics}, year={2010}, volume={87 4}, pages={545-52} }