Adiponectin attenuates endothelial dysfunction induced by oxidised low-density lipoproteins.

  title={Adiponectin attenuates endothelial dysfunction induced by oxidised low-density lipoproteins.},
  author={Stuart D Plant and Brett Shand and Peter A Elder and Russell S. Scott},
  journal={Diabetes & vascular disease research},
  volume={5 2},
We investigated whether the adipocytokine, adiponectin, protected the endothelium against damage induced by oxidised low-density lipoprotein cholesterol (oxLDL). Human umbilical vein endothelial cells were cultured with either 200 or 350 microg/ml oxLDL, with or without adiponectin purified from human serum (12 microg/ml). Cellular oxidative status was assessed by measuring reactive oxygen species (ROS), peroxynitrite and glutathione (GSH) levels, while cell function was evaluated by measuring… CONTINUE READING


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