Adiponectin as a growth inhibitor in prostate cancer cells.

@article{Bub2006AdiponectinAA,
  title={Adiponectin as a growth inhibitor in prostate cancer cells.},
  author={Jeffrey Bub and Toshiaki Miyazaki and Yoshiki Iwamoto},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={340 4},
  pages={
          1158-66
        }
}
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The regulation of adiponectin receptors in human prostate cancer cell lines.
The Role of Adiponectin in Prostate Cancer: A Narrative Review
TLDR
According to the results of these studies, decreased concentration of adiponectin was associated with increased risk of PCa and it seems that hypoadiponectinemia may act as a promising biomarker for detection and diagnosis ofPCa.
The Effects of Adiponectin and Leptin in the Proliferation of Prostate Cancer Cells
TLDR
The effects of leptin and adiponectin, which are the cytokines secreted from adipocytes, on prostate cancer in vitro and in vivo are analyzed and confirmed by in vivo experiment.
Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells.
TLDR
The results strongly suggest that the two adipokines should be considered as i) additional factors of breast cancer risk, and ii) may therefore be potential targets in breast cancer therapy.
1 Role of Adiponectin in prostate cancer
TLDR
This review focuses on the potential role of adiponectin and the underlying mechanism of adip onectin in the development and progression of prostate cancer and the signaling pathways linking adiponECTin with tumorigenesis might provide a potential target for therapy.
220 Role of Adiponectin in prostate cancer
TLDR
This review focuses on the potential role of adiponectin and the underlying mechanism of adip onectin in the development and progression of prostate cancer and the signaling pathways linking adiponECTin with tumorigenesis might provide a potential target for therapy.
Role of Adiponectin in prostate cancer
TLDR
The potential role of adiponectin and the underlying mechanism of adip onectin in the development and progression of prostate cancer is focused on.
Adiponectin ź³¼ Leptin ģ“ ģ „ė¦½ģ„ ģ•” ģ„øķ¬ģ˜ ģ¦ģ‹ģ— ėÆøģ¹˜ėŠ” ģ˜ķ–„ The Effects of Adiponectin and Leptin in the Proliferation of Prostate Cancer Cells
TLDR
The in vitro and in vivo finding suggested that adiponectin suppresses the proliferation of prostate cancer cells and that leptin plays an important role in the proliferation in the obese population.
Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95 2.
TLDR
It is concluded that adiponectin exerts direct anti-proliferative effects on HEC-1-A and RL95-2 cells by inducing cell cycle arrest and apoptosis, which provides a cellular mechanism underlying the linkages between endometrial cancer and obesity.
Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells.
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References

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TLDR
Leptin is identified as a novel growth factor in androgen-independent prostate cancer cell growth and adipose cytokines, as well as c-Jun NH2-terminal kinase, are key mediators between obesity and hormone-resistant prostate cancer and could be therapeutic targets.
Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin
TLDR
Data suggest that HMW adiponectin specifically confers the vascular-protective activities of this adipocytokine.
Prostate cancer cell proliferation is influenced by leptin.
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.
TLDR
Induction of endothelial apoptosis as an unique mechanism of adiponectin-induced antiangiogenesis may have therapeutic implications in the treatment of angiogenesis-dependent diseases.
Adiponectin activates c-Jun NH2-terminal kinase and inhibits signal transducer and activator of transcription 3.
Prostate cancer and adiponectin.
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TLDR
It is shown that there is a profound sexual dimorphism of Acrp30 levels and complex distribution in serum and a new model for in vivo activation of the protein, implicating a serum reductase activity is suggested.
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TLDR
The results indicate that adiponectin/ACRP30 deficiency and high TNF-Ī± levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
Disturbed secretion of mutant adiponectin associated with the metabolic syndrome.
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
TLDR
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
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