Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis.

@article{Sharma2010AdiponectinAT,
  title={Adiponectin antagonizes the oncogenic actions of leptin in hepatocellular carcinogenesis.},
  author={Dipali Sharma and Jason Wang and Ping Ping Fu and Shvetank Sharma and Arumugam Nagalingam and Jamie Eugene Mells and Jeffrey A Handy and Andrew J. Page and Cynthia Cohen and Frank A Anania and Neeraj Kumar Saxena},
  journal={Hepatology},
  year={2010},
  volume={52 5},
  pages={
          1713-22
        }
}
  • Dipali Sharma, Jason Wang, +8 authors Neeraj Kumar Saxena
  • Published in Hepatology 2010
  • Biology, Medicine
  • UNLABELLED Obesity is rapidly becoming a pandemic and is associated with increased carcinogenesis. Obese populations have higher circulating levels of leptin in contrast to low concentrations of adiponectin. Hence, it is important to evaluate the dynamic role between adiponectin and leptin in obesity-related carcinogenesis. Recently, we reported the oncogenic role of leptin including its potential to increase tumor invasiveness and migration of hepatocellular carcinoma (HCC) cells. In the… CONTINUE READING

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