Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease

@article{LaraCastro2007AdiponectinAT,
  title={Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease},
  author={Cristina Lara-Castro and Yu-chang Fu and B H Chung and W. Timothy Garvey},
  journal={Current Opinion in Lipidology},
  year={2007},
  volume={18},
  pages={263–270}
}
Purpose of review Adiponectin is secreted exclusively by adipocytes, aggregates in multimeric forms, and circulates at high concentrations in blood. This review summarizes recent studies highlighting cellular effects of adiponectin and its role in human lipid metabolism and atherosclerosis. Recent findings Adiponectin is an important autocrine/paracrine factor in adipose tissue that modulates differentiation of preadipocytes and favors formation of mature adipocytes. It also functions as an… Expand
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The data suggest that the plasma adiponectin concentration may not only link abdominal fat, insulin resistance, and dyslipidemia, but may also exert an independent role in regulating TRL metabolism in men. Expand
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Given the low levels of adiponectin in subjects with the metabolic syndrome, and the beneficial effect of the adipokine in animal studies, there is exciting potential for adiponECTin replacement therapy in insulin resistance and related disorders. Expand
Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism.
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The data suggest that the plasma adiponectin concentration may not only link abdominal fat, insulin resistance, and dyslipidemia, but may also exert an independent role in regulating TRL metabolism in men. Expand
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