Adiponectin and leptin are secreted through distinct trafficking pathways in adipocytes.

  title={Adiponectin and leptin are secreted through distinct trafficking pathways in adipocytes.},
  author={Linglin Xie and Cormac P O'Reilly and Stephen Keith Chapes and Silvia Quesada Mora},
  journal={Biochimica et biophysica acta},
  volume={1782 2},
Adiponectin and leptin are two adipokines secreted by white adipose tissue that regulate insulin sensitivity. Previously we reported that adiponectin but not leptin release depends on GGA-coated vesicle formation, suggesting that leptin and adiponectin may follow different secretory routes. Here we have examined the intracellular trafficking pathways that lead to the secretion of these two hormones. While adiponectin and leptin displayed distinct localization in the steady-state, treatment of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 60 references

Acute and chronic regulation of leptin synthesis , storage and secretion by insulin and dexamethasone in human adipose tissue

  • R. N. Petersen, S. P. Rao, +4 authors S. K. Fried
  • Am . J . Physiol . Endocrinol . Metab .
  • 2007

Similar Papers

Loading similar papers…