Adiponectin and adiponectin receptors.

  title={Adiponectin and adiponectin receptors.},
  author={Takashi Kadowaki and Toshimasa Yamauchi},
  journal={Endocrine reviews},
  volume={26 3},
Metabolic syndrome is thought to result from obesity and obesity-linked insulin resistance. [] Key Result Adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active "adipokines."Heterozygous peroxisome proliferator-activated receptor-gamma knockout mice were protected from high-fat diet induced obesity, adipocyte hypertrophy, and insulin resistance.
Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond.
It is proposed that deciphering the molecular details governing the adiponectin gene expression and protein secretion will lead to more comprehensive understanding of the mechanisms of insulin resistance in the adipose tissue and provide us new avenues for the therapeutic intervention of obesity and insulin resistance-related human disorders.
Role of leptin and adiponectin in insulin resistance.
Role of adiponectin system in insulin resistance.
  • C. Caselli
  • Biology, Medicine
    Molecular genetics and metabolism
  • 2014
Adiponectin: Probe of the molecular paradigm associating diabetes and obesity.
An attempt has been made to explore the relevance of adiponectin metabolism for the development of diabetes mellitus and identifies this novel target for prospective therapeutic research aiming successful management of Diabetes mellitus.
Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.
This review aims to summarize recent advances on delineation of the structural, molecular and cellular mechanisms underlying the hepato-protective properties of adiponectin.
Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exercise
Key findings to date suggest that changes in expression of AdipoR isoforms in skeletal muscle, rather than circulating total adiponectin levels, may be of physiological importance.
Intra-abdominal Fat Adiponectin Receptors Expression and Cardiovascular Metabolic Risk Factors in Obesity and Diabetes
IAAT-adipoR2 expression was reduced in obesity and diabetes and associated with components of metabolic processes leading to cardiovascular disease in obesity, and was related to plasma levels of FFA.
Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats.
Adiponectin and energy homeostasis
This review summarizes the progress of research about 1) the causal relationship of adiposity, energy intake, and adiponectin gene expression; and 2) the regulatory role of adip onectin in systemic energy metabolism.


The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Expression of adiponectin receptors in pancreatic beta cells.
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter.
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Adiponectin and resistin--new hormones of white adipose tissue.
  • J. Bełtowski
  • Medicine, Biology
    Medical science monitor : international medical journal of experimental and clinical research
  • 2003
The role of resistin in linking human obesity with type 2 diabetes is thus questionable, and this protein is detected in peripheral blood monocytes, which may contribute to insulin resistance and accelerated atherogenesis associated with obesity.
A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity.
It is suggested that increasing endogenous adiponectin levels has direct effects on insulin sensitivity and may induce similar physiological responses as prolonged treatment with peroxisomal proliferator-activated receptor gamma agonists.
Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis*
It is shown that replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis, and this is the first demonstration that globular leptin can protect against Atherosclerosis in vivo.
Importance of Adipocytokines in Obesity-Related Diseases
Plasma levels of adiponectin ranged from 0.3 to approximately 3 mg/dl but were decreased in patients with visceral obesity, type 2 diabetes and coronary artery disease (CAD), suggesting that hypoadiponectinemia may be considered an important risk factor for CAD.
Adiponectin and Metabolic Syndrome
The link of adiponectin to visceral adiposity, insulin resistance, and vascular diseases is discussed, and this novel adipocytokine has plural biofunctions, such as antidiabetic, antiatherosclerotic, and antiinflammatory functions.