Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.

@article{Zhou2009AdiponectinAA,
  title={Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.},
  author={Lijun Zhou and Sathyaseelan S Deepa and Julie C Etzler and Jiyoon Ryu and Xuming Mao and Qichen Fang and Dianna D Liu and Jes{\'u}s M. Torres and Weiping Jia and James D Lechleiter and Feng Liu and Lily Q. Dong},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 33},
  pages={
          22426-35
        }
}
The binding of the adaptor protein APPL1 to adiponectin receptors is necessary for adiponectin-induced AMP-activated protein kinase (AMPK) activation in muscle, yet the underlying molecular mechanism remains unknown. Here we show that in muscle cells adiponectin and metformin induce AMPK activation by promoting APPL1-dependent LKB1 cytosolic translocation. APPL1 mediates adiponectin signaling by directly interacting with adiponectin receptors and enhances LKB1 cytosolic localization by… CONTINUE READING
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