Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells

  title={Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells},
  author={Raogo Ouedraogo and Xiangdong Wu and Shi-qiong Xu and Lauren Fuchsel and Hiroyuki Motoshima and Kalyankar Mahadev and Kelly Hough and Rosario Scalia and Barry J. Goldstein},
  pages={1840 - 1846}
Adiponectin is an abundant adipocyte-derived plasma protein with antiatherosclerotic effects. Vascular signal transduction by adiponectin is poorly understood and may involve 5′-AMP–activated protein kinase (AMPK), cAMP signaling, and other pathways. Hyperglycemia sharply increases the production of reactive oxygen species (ROS), which play a key role in endothelial dysfunction in diabetes. Because the recombinant globular domain of human adiponectin (gAd) reduces the generation of endothelial… 

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