Adiponectin Isoforms in Elderly Patients with or without Coronary Artery Disease

@article{Rizza2010AdiponectinII,
  title={Adiponectin Isoforms in Elderly Patients with or without Coronary Artery Disease},
  author={Stefano Rizza and Fabrizio Gigli and Angelica Galli and B. Micchelini and Davide Lauro and Renato Lauro and Massimo Federici},
  journal={Journal of the American Geriatrics Society},
  year={2010},
  volume={58}
}
OBJECTIVES: To study the distribution of adiponectin isoforms in a group of very old patients. 
View on Wiley
ncbi.nlm.nih.gov
44 Citations
Background Citations
15
Methods Citations
1

44 Citations

Citation Type

Citation Type

DO ADIPONECTIN ISOFORMS IN OLDER ADULTS WITH OR WITHOUT CORONARY ARTERY DISEASE DIFFER ACCORDING TO GLUCOSE TOLERANCE STATES AND LIFESTYLE FACTORS?
TLDR
The authors have no financial or any other kind of personal conflicts with this paper and the editor in chief has reviewed the conflict of interest checklist provided by the authors.
Reduced high‐molecular‐weight adiponectin is an independent risk factor for cardiovascular lesions in hypercholesterolaemic patients
TLDR
This study determined the circulatory distribution of APN multimers and their relationships with cardiovascular disease (CVD)‐related biochemical indicators in patients with hypercholesterolaemia (HC).
Plasma adiponectin: a possible link between fat metabolism and pancreatic cancer risk.
TLDR
It is reported that a fat-derived hormone adiponectin in the circulation is inversely associated with pancreatic cancer risk, and the adiponECTin-tumor risk association is independent of sex, age, smoking status, and other potential risk factors.
Correlation between plasma ZAG and adiponectin in older adults: gender modification and frailty specificity
TLDR
Plasma ZAG is an independent factor of plasma adiponectin, especially in older male adults, and both of ZAG and adip onectin may be potential frailty biomarkers.
Assessment of adiponectin and its isoforms in Polish centenarians
The role of adipokines in the pathogenesis of gestational diabetes mellitus
  • G. de Gennaro, G. Palla, C. Bianchi
  • Biology, Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2019
TLDR
The potential physiopathological and prognostic role in GDM of adipokines, mainly APN and LPT, is outlined, which may contribute directly and indirectly through the enhancement of chronic inflammation, aggravating insulin resistance and promoting GDM onset.
The Role of Serum Magnesium and Calcium on the Association between Adiponectin Levels and All-Cause Mortality in End-Stage Renal Disease Patients
TLDR
The predictive value of ADPN in all-cause mortality in end-stage renal disease patients appears to be critically dependent on s-Mg and s-Ca levels, which may impact on clinical outcomes by directly modifying the ADPN’s bioactivity.
Plasma Adiponectin Levels Correlate Positively with an Increasing Number of Components of Frailty in Male Elders
TLDR
Plasma adiponectin levels correlate positively with an increasing number of components of frailty in male elders and the difference between the sexes suggests that certain sex-specific mechanisms may exist to affect the association between adiponECTin levels and frailty.
Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis.
Reciprocal Effects of Systemic Inflammation and Brain Natriuretic Peptide on Adiponectin Biosynthesis in Adipose Tissue of Patients With Ischemic Heart Disease
TLDR
This study demonstrates the regional variability in the responsiveness of human adipose tissue to systemic inflammation and suggests that BNP is the main driver of circulating adiponectin in patients with advanced atherosclerosis even in the absence of HF.
...
...

References

SHOWING 1-10 OF 28 REFERENCES
Adiponectin and cardiovascular disease: state of the art?
TLDR
The pathophysiology of adiponectin in atherosclerotic disease is described, which seems to possess antiatherogenic and anti-inflammatory effects and may be protective against cardiovascular disease development.
Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD.
Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study.
TLDR
The results suggest that use of adiponectin for cardiovascular disease risk stratification is premature, and suggest that high density lipoprotein cholesterol and/or triglycerides eliminated this association.
Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease.
TLDR
Measurement of total and HMW adip onectin were equally useful in assessing metabolic risk in CAD patients, and change in the HMW isoform reflects a change in total adiponectin level.
Adiponectin and Cardiovascular Disease
Adiponectin and cardiovascular disease.
TLDR
Experimental findings have shown that adiponectin has beneficial effects in the cardiovascular system by directly acting on the component cells of the heart and blood vessels, and could be a promising therapeutic target for cardiovascular diseases.
Adiponectin and risk of coronary heart disease in older men and women.
TLDR
This study shows an association between adiponectin and increased risk of first-ever CHD in older adults, and further research is needed to elucidate the basis for the concurrent beneficial and detrimental aspects of this relationship, and under what circumstances one or the other may predominate.
Prognostic value of adiponectin for cardiovascular disease and mortality.
TLDR
It is hypothesized that adiponectin protects against metabolic and vascular diseases, but in patients already afflicted with CVD, adip onectin is compensatory up-regulated and, therefore, indicates a high mortality risk.
An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women.
TLDR
Investigation of diet-induced weight loss improved insulin sensitivity as well as increased the amount of HMW, MMW and LMW adiponectin complexes in plasma found no correlations between changes in adiponECTin complexes and changes in indices of insulin sensitivity.
Adiponectin and Coronary Heart Disease: A Prospective Study and Meta-Analysis
TLDR
In contrast to the strong associations previously reported between adiponectin levels and risk of type 2 diabetes, any association with CHD risk is comparatively moderate and requires further investigation.
...
...