Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities

@article{Lam2009AdiponectinHP,
  title={Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities},
  author={Janice B. B. Lam and Kim H. M. Chow and Aimin Xu and Karen Siu-Ling. Lam and Jing Liu and N K S Wong and Randall T. Moon and P. R. Shepherd and Garth J S Cooper and Yu Wang},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={128 - 145}
}
BACKGROUND Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications. A negative association of adiponectin levels with breast cancer development has been demonstrated. However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive. METHODOLOGY/PRINCIPAL FINDINGS In the present study, MMTV-polyomavirus middle T antigen (MMTV-PyVT) transgenic mice with reduced adiponectin expressions were established and the stromal… CONTINUE READING

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