Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice

  title={Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced Obesity Mice},
  author={Lan Zhang and Shu Xian Meng and Qisheng Tu and Liming Yu and Yin Tang and Michel M. Dard and Sung-Hoon Kim and P. Cinjordis Valverde and Xuedong Zhou and Jake Jinkun Chen},
  booktitle={PloS one},
Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced obesity mice, a model of obesity and type 2 diabetes, and aimed at evaluating the therapeutic potential of adiponectin. We found that systemic adiponectin infusion reduced alveolar bone loss, osteoclast activity and infiltration of inflammatory… CONTINUE READING


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