Adiponectin: from obesity to cardiovascular disease

  title={Adiponectin: from obesity to cardiovascular disease},
  author={C. Antoniades and A. Antonopoulos and D. Tousoulis and C. Stefanadis},
  journal={Obesity Reviews},
  • C. Antoniades, A. Antonopoulos, +1 author C. Stefanadis
  • Published 2009
  • Medicine
  • Obesity Reviews
  • Adiponectin is an adipokine whose biosynthesis is deranged in obesity and diabetes mellitus, predisposing to atherosclerosis. Evidence suggests that adiponectin has anti‐atherogenic properties by improving endothelial function and having anti‐inflammatory effects in the vascular wall. In addition, adiponectin modifies vascular intracellular redox signalling and exerts indirect antioxidant effects on human myocardium. However, its clinical role in cardiovascular disease is obscure. Adiponectin's… CONTINUE READING
    181 Citations
    Relationship between adiponectin, obesity and insulin resistance.
    • 97
    • PDF
    The molecular mechanisms of obesity paradox.
    • 70
    Inflammation: The Link Between Obesity and Cardiovascular Risk
    • 2
    • Highly Influenced
    The role of adiponectin in human vascular physiology.
    • 84
    • PDF
    The interplay between adipose tissue and the cardiovascular system: is fat always bad?
    • 50
    • PDF
    Genetic variability on adiponectin gene affects myocardial infarction risk: the role of endothelial dysfunction.
    • 21
    Coronary Atherosclerosis: Adiponectin and Leptin as Predictors of Disease Severity
    • 4
    • PDF


    Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease.
    • 177
    • Highly Influential
    Adiponectin, obesity, and cardiovascular disease.
    • 125
    Adiponectin and future coronary heart disease events among men with type 2 diabetes.
    • 362
    • PDF
    Adiponectin and mortality in patients undergoing coronary angiography.
    • 124
    • PDF
    Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure.
    • 88
    • PDF
    Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease.
    • 98
    Adiponectin plasma levels are increased by atorvastatin treatment in subjects at high cardiovascular risk.
    • 37
    Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study.
    • 210
    • PDF