Adiponectin: An adipokine linking adipocytes and type 2 diabetes in humans
@article{Hara2005AdiponectinAA, title={Adiponectin: An adipokine linking adipocytes and type 2 diabetes in humans}, author={Kazuo Hara and Toshimasa Yamauchi and Takashi Kadowaki}, journal={Current Diabetes Reports}, year={2005}, volume={5}, pages={136-140} }
Adipocyte-derived adiponectin is an insulin-sensitizing and antiatherosclerotic hormone, and replenishment of adiponectin in animal models ameliorated insulin resistance and atherosclerosis. In humans, recent studies have demonstrated that adiponectin level is a good predictor of developing type 2 diabetes and coronary artery disease. Decreasing level of adiponectin is caused by the interaction between genetic factors, such as single nucleotide polymorphisms in the adiponectin gene, and…
70 Citations
Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes.
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Regulation of adiponectin or AdipoR expression may be of great importance in the development of metabolic perturbations characteristic of Type 2 diabetes in obese individuals.
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The effects of exercise training on adiposity, insulin resistance, and inflammatory markers among obese male Korean adolescents and adiponectin are studied to study the association between these markers and obesity.
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Interestingly, adiponectin has been shown to exert actions in the female reproductive system, including the hypothalamic–pituitary–ovarian axis and the endometrium, and the placenta, and its concentrations and effects have been assessed in some pregnancy-associated disorders and gynecological conditions.
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Although there are differences in isoforms between species, in all cases pioglitazone served to increase the secretion of the HMW form of adiponectin, with no significant effect on the other isoforms.
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