Adiponectin: An adipokine linking adipocytes and type 2 diabetes in humans

  title={Adiponectin: An adipokine linking adipocytes and type 2 diabetes in humans},
  author={Kazuo Hara and Toshimasa Yamauchi and Takashi Kadowaki},
  journal={Current Diabetes Reports},
Adipocyte-derived adiponectin is an insulin-sensitizing and antiatherosclerotic hormone, and replenishment of adiponectin in animal models ameliorated insulin resistance and atherosclerosis. In humans, recent studies have demonstrated that adiponectin level is a good predictor of developing type 2 diabetes and coronary artery disease. Decreasing level of adiponectin is caused by the interaction between genetic factors, such as single nucleotide polymorphisms in the adiponectin gene, and… 
Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes.
Regulation of adiponectin or AdipoR expression may be of great importance in the development of metabolic perturbations characteristic of Type 2 diabetes in obese individuals.
Adipokines and insulin resistance during pregnancy.
The emerging role of adiponectin in cerebrovascular and neurodegenerative diseases.
Improved Insulin Sensitivity and Adiponectin Level after Exercise Training in Obese Korean Youth
The effects of exercise training on adiposity, insulin resistance, and inflammatory markers among obese male Korean adolescents and adiponectin are studied to study the association between these markers and obesity.
The Emerging Roles of Adiponectin in Female Reproductive System-Associated Disorders and Pregnancy
Interestingly, adiponectin has been shown to exert actions in the female reproductive system, including the hypothalamic–pituitary–ovarian axis and the endometrium, and the placenta, and its concentrations and effects have been assessed in some pregnancy-associated disorders and gynecological conditions.
Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes.
Although there are differences in isoforms between species, in all cases pioglitazone served to increase the secretion of the HMW form of adiponectin, with no significant effect on the other isoforms.
Reduced serum vaspin concentrations in obese children following short-term intensive lifestyle modification.


The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Adiponectin and development of type 2 diabetes in the Pima Indian population
Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin.
Body weight reduction increased the plasma levels of a protective adipocytokine, adiponectin, despite the reduction of the only tissue of its own synthesis, suggesting that the expression of adip onectin is under feedback inhibition in obesity.
The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects.
The findings show that TZD treatment increased adiponectin levels in all subjects, including normal subjects in which no other effects of TZDs are observed, and it may play a physiologic role in enhancing insulin sensitivity.
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.
Reduction in circulating adiponectin may be related to the development of insulin resistance in rhesus monkeys, which spontaneously develop obesity and which subsequently frequently progress to overt type 2 diabetes.
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.
It is confirmed that obesity and type 2 diabetes are associated with low plasma adiponectin concentrations in different ethnic groups and indicate that the degree of hypoadiponectinemia is more closely related to thedegree of insulin resistance and hyperinsulinemia than to the level of adiposity and glucose intolerance.
Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.
The findings suggest that I164T mutation is associated with low plasma adiponectin concentration and type 2 diabetes.