Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies

  title={Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies},
  author={Francis Vasseur and David Meyre and Philippe Froguel},
  journal={Expert Reviews in Molecular Medicine},
  pages={1 - 12}
Adiponectin, a protein exclusively secreted by adipose tissue but present at low levels in obesity, is now widely recognised as a key determinant of insulin sensitivity and of protection against obesity-associated metabolic syndrome. In this review we explain how genetic findings have contributed to a better understanding of the physiological role of adiponectin in humans. The adiponectin-encoding gene, ADIPOQ (ACDC), is very polymorphic: many frequent exonic synonymous, intronic and promoter… 
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