• DOI:10.1152/ajprenal.00263.2013
• Corpus ID: 7630020

Adipokines as a link between obesity and chronic kidney disease.

@article{Briffa2013AdipokinesAA,
  title={Adipokines as a link between obesity and chronic kidney disease.},
  author={Jessica F. Briffa and Andrew J. McAinch and Philip Poronnik and Deanne H. Hryciw},
  journal={American journal of physiology. Renal physiology},
  year={2013},
  volume={305 12},
  pages={
          F1629-36
        }
}

• J. Briffa, A. McAinch, +1 author D. Hryciw
• Published 15 December 2013
• Biology, Medicine
• American journal of physiology. Renal physiology

Adipocytes secrete a number of bioactive adipokines that activate a variety of cell signaling pathways in central and peripheral tissues. Obesity is associated with the altered production of many adipokines and is linked to a number of pathologies. As an increase in body weight is directly associated with an increased risk for developing chronic kidney disease (CKD), there is significant interest in the link between obesity and renal dysfunction. Altered levels of the adipokines leptin, adiponectin, resistin, and visfatin can decrease the glomerular filtration rate and increase albuminuria, which are pathophysiological changes typical of CKD. Specifically, exposure of the glomerulus to altered adipokine levels can increase its permeability, fuse the podocytes, and cause mesangial cell hypertrophy, all of which alter the glomerular filtration rate. In addition, the adipokines leptin and adiponectin can act on tubular networks. Thus, adipokines can act on multiple cell types in the development of renal pathophysiology. Importantly, most studies have been performed using in vitro models, with future studies in vivo required to further elucidate the specific roles that adipokines play in the development and progression of CKD.