Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cells.

@article{Pasarica2008AdipogenicHA,
  title={Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cells.},
  author={Magdalena Pasarica and Nazar Mashtalir and Emily J McAllister and Gail E. Kilroy and Juraj Koska and Paska A. Permana and Barbora de Courten and Minghuan Yu and Eric Ravussin and Jeffrey M. Gimble and Nikhil V Dhurandhar},
  journal={Stem cells},
  year={2008},
  volume={26 4},
  pages={969-78}
}
Human adenovirus Ad-36 is causatively and correlatively linked with animal and human obesity, respectively. Ad-36 enhances differentiation of rodent preadipocytes, but its effect on adipogenesis in humans is unknown. To indirectly assess the role of Ad-36-induced adipogenesis in human obesity, the effect of the virus on commitment, differentiation, and lipid accumulation was investigated in vitro in primary human adipose-derived stem/stromal cells (hASC). Ad-36 infected hASC in a time- and dose… CONTINUE READING

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