Adipogenesis and aging: does aging make fat go MAD?

@article{Kirkland2002AdipogenesisAA,
  title={Adipogenesis and aging: does aging make fat go MAD?},
  author={James l. Kirkland and Tamara T. Tchkonia and Tamar Pirtskhalava and Jianrong Han and Iordanes Karagiannides},
  journal={Experimental Gerontology},
  year={2002},
  volume={37},
  pages={757-767}
}
In advanced old age, fat depot size declines while lipid is redistributed to muscle, bone marrow, and other tissues. Decreased fat depot size is related to reduced fat cell size and function and impaired differentiation of preadipocytes into fat cells. Reduced differentiation-dependent gene expression results from decreased abundance of the adipogenic transcription factors, CCAAT/enhancer binding alpha (C/EBPalpha) and peroxisome proliferator activated receptor gamma (PPARgamma). Increased… CONTINUE READING
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