Adipogenesis: from stem cell to adipocyte.

@article{Tang2012AdipogenesisFS,
  title={Adipogenesis: from stem cell to adipocyte.},
  author={Qi Qun Tang and Melissa D. Lane},
  journal={Annual review of biochemistry},
  year={2012},
  volume={81},
  pages={715-36}
}
Excessive caloric intake without a rise in energy expenditure promotes adipocyte hyperplasia and adiposity. The rise in adipocyte number is triggered by signaling factors that induce conversion of mesenchymal stem cells (MSCs) to preadipocytes that differentiate into adipocytes. MSCs, which are recruited from the vascular stroma of adipose tissue, provide an unlimited supply of adipocyte precursors. Members of the BMP and Wnt families are key mediators of stem cell commitment to produce… CONTINUE READING
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