Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.

@article{Wang2007AdipocytokinesAT,
  title={Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice.},
  author={Zhihui Wang and Michal M. Masternak and Khalid A Al-Regaiey and Andrzej Bartke},
  journal={Endocrinology},
  year={2007},
  volume={148 6},
  pages={2845-53}
}
Chronic elevation of GH induces resistance to insulin and hyperinsulinemia in both humans and animals, whereas calorie restriction (CR) improves peripheral insulin sensitivity in many species. To investigate the mechanisms that lead to insulin resistance in animals with high levels of GH as well as the mechanisms that might improve insulin sensitivity, we fed GH-overexpressing transgenic mice ad libitum or subjected them to 30% CR. We then assayed the plasma adipocytokines levels related to… CONTINUE READING
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