Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid.

@article{McClain2005AdipocytesWI,
  title={Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid.},
  author={Donald A. McClain and Mark Hazel and Glendon J Parker and Robert C. Cooksey},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={288 5},
  pages={E973-9}
}
The hexosamine signaling pathway has been shown to serve a nutrient-sensing function. We have previously shown that overexpression of the rate-limiting enzyme for hexosamine synthesis (glutamine-fructose-6-phosphate amidotransferase) in adipose tissue of transgenic mice results in skeletal muscle insulin resistance and altered regulation of leptin and adiponectin. To dissect the pathways by which the hexosamine pathway affects fuel storage and energy homeostasis, we have examined the… CONTINUE READING