Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regulated manner

@article{Abella2004AdipocytesRA,
  title={Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regulated manner},
  author={Anna Abella and Silvia Garc{\'i}a-Vicente and Nathalie Viguerie and A. Ros-Bar{\'o} and M. Ben{\'i}tez Camps and Manuel Palac{\'i}n and Antonio Zorzano and Luc Marti},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={429-438}
}
Vascular adhesion protein-1 (VAP-1), which is identical to semicarbazide-sensitive amine oxidase (SSAO), is a dual-function membrane protein with adhesion properties and amine oxidase activity. A soluble form of VAP-1 is found in serum, where concentrations are enhanced in diabetes and obesity. In vitro, soluble VAP-1 enhances lymphocyte adhesion to endothelial cells, thus possibly participating in the enhanced lymphocyte adhesion capacity that is implicated in the cardiovascular complications… CONTINUE READING
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