Adipocytes of old rats produce a decreased amount of differentiation factor for preadipocytes derived from adipose tissue islets.

@article{Carraro1992AdipocytesOO,
  title={Adipocytes of old rats produce a decreased amount of differentiation factor for preadipocytes derived from adipose tissue islets.},
  author={Raffaele Carraro and Zhixiong H Li and James Elton Johnson and Robert I. Gregerman},
  journal={Journal of gerontology},
  year={1992},
  volume={47 6},
  pages={
          B198-201
        }
}
Adipose tissue of young rats (3.5 mo) contains cell formations ("islets") that, in culture, give rise to a variety of preadipocytes, or islet-derived cells (IDCs), that undergo rapid morphologic differentiation into adipocytes. Such adipose conversion depends on a differentiation-promoting factor produced by the mature adipocytes also present in the cultures. Here we report that cultured IDCs from epididymal fat of senescent rats (20 +/- 3 mo) show decreased adipose conversion compared to IDCs… CONTINUE READING
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