Adipocytes modulate the phenotype of human macrophages through secreted lipids.

@article{KleinWieringa2013AdipocytesMT,
  title={Adipocytes modulate the phenotype of human macrophages through secreted lipids.},
  author={Inge R. Klein-Wieringa and Stefan N. Andersen and Joanneke C. Kwekkeboom and Martin Giera and Badelog J. E. de Lange-Brokaar and Gerjo J. V. M. van Osch and A Zuurmond and Vedrana Stojanovic-Susulic and Rob G. H. H. Nelissen and Hanno Pijl and Tom W. J. Huizinga and Margreet Kloppenburg and Ren{\'e} E. M. Toes and Andreea Ioan-Facsinay},
  journal={Journal of immunology},
  year={2013},
  volume={191 3},
  pages={1356-63}
}
Previous studies have shown accumulation and an enhanced proinflammatory profile of macrophages in adipose tissue of obese mice, indicating the presence of an interaction between adipocytes and macrophages in this tissue. However, the consequences of this interaction in humans are yet incompletely understood. In this study, we explored the modulating… CONTINUE READING