Adipocytes decrease Runx2 expression in osteoblastic cells: roles of PPARγ and adiponectin.

@article{Liu2010AdipocytesDR,
  title={Adipocytes decrease Runx2 expression in osteoblastic cells: roles of PPARγ and adiponectin.},
  author={Li-fen Liu and Wen-Jun Shen and Zhong Hua Zhang and Li Juan Wang and Fredric B Kraemer},
  journal={Journal of cellular physiology},
  year={2010},
  volume={225 3},
  pages={837-45}
}
The mechanisms through which bone marrow adipocytes might influence differentiation and function of osteoblasts are not completely understood. To investigate the direct effects of bone marrow fat cells on osteoblast function, an ex vivo co-culture system was utilized comprising either primary fat cells or differentiated 3T3-L1 adipocytes and osteoblastic cells on transwells. In co-culture, both adipocytes and osteoblastic cells were differentiated into adipocytes or osteoblasts, respectively… CONTINUE READING

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