Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.

@article{Kershaw2005AdipocytespecificGI,
  title={Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.},
  author={Erin E Kershaw and Nicholas M Morton and Harveen Dhillon and Lynne Ramage and Jonathan R Seckl and Jeffrey S. Flier},
  journal={Diabetes},
  year={2005},
  volume={54 4},
  pages={1023-31}
}
Local glucocorticoid (GC) action depends on intracellular GC metabolism by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). 11betaHSD1 activates GCs, while 11betaHSD2 inactivates GCs. Adipocyte-specific amplification of GCs through transgenic overexpression of 11betaHSD1 produces visceral obesity and the metabolic syndrome in mice. To determine whether adipocyte-specific inactivation of GCs protects against this phenotype, we created a transgenic model in which human 11betaHSD2 is expressed… CONTINUE READING

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