Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity, but results in insulin resistance.

@article{Xiong2018AdipocytespecificDO,
  title={Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity, but results in insulin resistance.},
  author={Yan Xiong and Ziye Xu and Yizhen Wang and Shihuan Kuang and Tizhong Shan},
  journal={Journal of lipid research},
  year={2018},
  volume={59 6},
  pages={
          974-981
        }
}
Liver kinase B1 (Lkb1) and mammalian target of rapamycin (mTOR) are key regulators of energy metabolism and cell growth. We have previously reported that adipocyte-specific KO of Lkb1 or mTOR in mice results in distinct developmental and metabolic phenotypes. Here, we aimed to assess how genetic KO of both Lkb1 and mTOR affects adipose tissue development… CONTINUE READING