Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation
@article{Khn2012AdipocytesecretedFI, title={Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation}, author={Markus C. K{\"u}hn and Holger Sven Willenberg and Matthias Schott and Claudia Papewalis and Ulla Stumpf and Sascha Flohe and Werner A. Scherbaum and Sven Schinner}, journal={Molecular and Cellular Endocrinology}, year={2012}, volume={349}, pages={180-188} }
57 Citations
Interleukin 6 and/or Interleukin 17A Modulate the OPG/RANKL System of MC3T3-E1 Murine Osteoblast Cell Line
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Findings suggest a new mechanism of regulation by these cytokines on the expression of OPG and RANKL, which could promote osteogenesis and diminish osteoclastogenesis.
The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro
- BiologyInternational journal of endocrinology
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It is found that osthole exerted a potent ability to promote proliferation and osteogenic function of rat bone marrow stromal cells and osteoblasts, and the prenyl group plays an important role in these bone-protective effects.
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines
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The current study is the first to reveal that dioscin can promote osteoblasts proliferation and differentiation via Lrp5 and ER pathway.
Osteoblasts subjected to tensile force induce osteoclastic differentiation of murine macrophages in a coculture system
- Biology, Medicine
- 2015
The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice
- Medicine, BiologyCell Communication and Signaling
- 2019
It is demonstrated that T007 impedes osteoclastogenesis and will be useful for the therapy of bone related diseases, essentially osteoporosis.
Intercellular Cross-Talk Among Bone Cells: New Factors and Pathways
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- 2012
Recent work that provides new insights into some of the communication networks and the factors involved are discussed, including osteocytic production of receptor activator of nuclear factor-κB ligand and sclerostin, osteoblastic production of interleukin-33, osteoclast-derived Semaphorin 4D, ephrin signaling, and signals from T helper cells and resident osteal macrophages.
Fibroblast growth factor 2 exacerbates inflammation in adipocytes through NLRP3 inflammasome activation.
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FGF2 is an adipokine that may exacerbate the inflammatory response in adipocytes through NLRP3 inflammasome activation, which is suggested to be a major risk factor for the development of obesity-induced insulin resistance.
Treatment with an inhibitor of fatty acid synthase attenuates bone loss in ovariectomized mice.
- Biology, MedicineBone
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Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo
- BiologyEvidence-based complementary and alternative medicine : eCAM
- 2020
Investigating the antiosteoporotic effects of CC extracts in in vitro cell cultures and in vivo bone loss animal models suggests that CC extract may be considered as a natural therapeutic or preventive agent for osteoporosis.
Effects of Scytosiphon lomentaria on osteoblastic proliferation and differentiation of MC3T3-E1 cells
- Biology, MedicineNutrition research and practice
- 2016
Treatment of Scytosiphon lomentaria extract is demonstrated to promote differentiation inducement and proliferation of osteoblasts and, therefore, may help to elucidate the transcriptional mechanism of bone formation and possibly lead to the development of bone-forming drugs.
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