Adipocyte morphology and implications for metabolic derangements in acquired obesity

@article{Heinonen2014AdipocyteMA,
  title={Adipocyte morphology and implications for metabolic derangements in acquired obesity},
  author={Sini Heinonen and Lilli Saarinen and Jussi Naukkarinen and Amaia Rodr{\'i}guez and Gema Fr{\"u}hbeck and A Hakkarainen and Jesse Lundbom and Nina Lundbom and Katriina Vuolteenaho and Eeva Moilanen and Peter Arner and Sampsa Hautaniemi and Anu Suomalainen and Jaakko M Kaprio and Aila M. Rissanen and K. H. Pietil{\"a}inen},
  journal={International Journal of Obesity},
  year={2014},
  volume={38},
  pages={1423-1431}
}
Background:Adipocyte size and number have been suggested to predict the development of metabolic complications in obesity. However, the genetic and environmental determinants behind this phenomenon remain unclear.Methods:We studied this question in rare-weight discordant (intra-pair difference (Δ) body mass index (BMI) 3–10 kg m−2, n=15) and concordant (ΔBMI 0–2 kg m−2, n=5) young adult (22–35 years) monozygotic twin pairs identified from 10 birth cohorts of Finnish twins (n=5 500 pairs… CONTINUE READING