Adipocyte-mononuclear cell interaction, Toll-like receptor 4 activation, and high glucose synergistically up-regulate osteopontin expression via an interleukin 6-mediated mechanism.

@article{Samuvel2010AdipocytemononuclearCI,
  title={Adipocyte-mononuclear cell interaction, Toll-like receptor 4 activation, and high glucose synergistically up-regulate osteopontin expression via an interleukin 6-mediated mechanism.},
  author={Devadoss John Samuvel and Kamala P. Sundararaj and Yanchun Li and MariaF. Lopes-Virella and Yan Huang},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 6},
  pages={
          3916-27
        }
}
Although it has been reported that osteopontin, a matrix glycoprotein and proinflammatory cytokine, mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance, it remains unclear how osteopontin is up-regulated in adipose tissue in obese humans and animals. In this study, we incubated U937 mononuclear cells with adipocytes in a transwell system and studied how cell interaction regulated osteopontin expression. Results showed that coculture of U937 cells with… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-2 OF 2 REFERENCES

Adipocyte-Mononuclear Cell Interaction Increases Osteopontin 3926 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • P. G. Cammisotto, Y. Gélinas, Y. Deshaies, L. J. Bukowiecki
  • Am. J. Physiol. Endocrinol. Metab. 285,
  • 2010
1 Excerpt

NUMBER 6 JOURNAL OF BIOLOGICAL CHEMISTRY 3927 at G eogian C ourt C olege on M arch

  • M. A. Syed, E. Barinas-Mitchell, +9 authors M. Pietropaolo
  • Diabetes Nutr. Metab
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…