Adipocyte modulation of high-density lipoprotein cholesterol.

  title={Adipocyte modulation of high-density lipoprotein cholesterol.},
  author={Yuzhen Zhang and Fiona C McGillicuddy and Christine Hinkle and Sean O'Neill and Jane M. Glick and George H. Rothblat and Muredach P. Reilly},
  volume={121 11},
BACKGROUND Adipose harbors a large depot of free cholesterol. However, a role for adipose in cholesterol lipidation of high-density lipoprotein (HDL) in vivo is not established. We present the first evidence that adipocytes support transfer of cholesterol to HDL in vivo as well as in vitro and implicate ATP-binding cassette subfamily A member 1 (ABCA1) and scavenger receptor class B type I (SR-BI), but not ATP-binding cassette subfamily G member 1 (ABCG1), cholesterol transporters in this… CONTINUE READING


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