Adipocyte-fatty acid binding protein induces apoptosis in DU145 prostate cancer cells.

@article{Santis2004AdipocytefattyAB,
  title={Adipocyte-fatty acid binding protein induces apoptosis in DU145 prostate cancer cells.},
  author={Marta L De Santis and Rasha Hammamieh and Rina Das and Marty Jett},
  journal={Journal of experimental therapeutics & oncology},
  year={2004},
  volume={4 2},
  pages={91-100}
}
Adipocyte-fatty acid binding protein (A-FABP) is a 14-15 kDa cytoplasmic protein that binds unesterified fatty acids (FA). It is believed that A-FABP is present in normal cells and disappears in cancer cells. Prostate cancer DU145 cells lack expression of A-FABP. Here, we report that transfection of A-FABP blocked growth of DU145 cells suggesting its role as a tumor suppressor. A-FABP transfected- prostate cancer DU145 cells underwent apoptosis when induced to overexpress A-FABP using an… CONTINUE READING
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